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Making a baby isn't always easy. Fortunately, there are many ways to parenthood. In vitro fertilization, or IVF, brings the miracle of conception into a laboratory. It has led to the birth of nearly 10 million babies since the first successful fertilization procedure in 1978. So how does it work? Let's take a closer, step-by-step look at the process in this article further.
In the modern era, in vitro fertilization or the IVF has become a household term, offering hope to millions of couples struggling with infertility. With the passage of each minute, more and more couples are fulfilling their dream of having biological children. However, behind this marvel of medical science lies a lesser known tale of determination, innovation and hard work of countless extraordinary individuals who paved the way for this groundbreaking technique.
18th Century: Into the History
The story begins in the 18th century with the curiosity of scientists and philosophers who dared to question the mysteries of human conception. The brilliant Italian physiologist, Lazaro Spallanzani conducted experiments on animals seeking to unravel the intricacies of fertilization. His pioneering work laid the foundation for future advancements in reproductive science.
20th Century: This Day
Fast forward to the early 20th century when the extraordinary achievements of unsung heroes like Dr. Gregory Pincus and Dr. Ming-Chui Chang went largely unnoticed. Through tireless dedication, these two visionaries paved the way for the development of oral contraceptives which eventually led to significant breakthroughs in understanding reproductive biology. Now, the year is 1978 and a British team of doctors and scientists led by Dr. Patrick Steptoe and Dr. Robert Edwards is on the brink of making history. They had spent years perfecting a technique called in vitro fertilization but success remained elusive. It wasn't until the birth of Louise Brown, the world's first IVF baby that the world realized the immense potential of this revolutionary procedure. The news spread like wildfire offering hope to countless couples who had previously been deemed infertile.
The birth of Louise Brown opened a Pandora's box of ethical questions and raised concerns within society. Some feared that IVF would disrupt the natural order of reproduction or pave the way for designer babies. However, the medical community diligently addressed these concerns ensuring that the procedure's safety and adhering to strict regulations and guidelines.
Over time, public opinion gradually shifted recognizing the incredible benefits IVF brought to families worldwide. With the birth of IVF, a new era of reproductive medicine dawned. Scientists and physicians continued to refine and expand the boundaries of assisted reproductive technologies.
· Intracytoplasmic sperm injection or the ICSI emerged in the 1990s enabling couples with severe male infertility to conceive.
· Cryopreservation techniques allowed for the freezing and storage of embryos extending the possibilities of timing and planning in assisted reproductive procedures.
· Pre-implantation genetic testing or the PGT emerged as a transformative tool empowering parents to screen embryos for genetic abnormalities before implantation.
This not only enhanced the chances of healthy offspring but also provided an opportunity to mitigate the transmission of hereditary diseases. The introduction of advanced culture media, time-lapse imaging systems and endometrial receptivity assays further augmented the success rates of IVF treatment. As IVF evolved, its applications extended beyond infertility.
Same-sex couples, single individuals and those with medical conditions that compromise fertility gained the opportunity to fulfill their dreams of parenthood. Surrogacy, donor eggs or sperm and fertility preservation for cancer patients became a reality further enriching the possibilities offered by IVF. The journey does not end here.
Ongoing research explores cutting-edge techniques such as mitochondrial replacement therapy artificial wombs and gene editing to address infertility and eradicate genetic disorders. The future holds immense promise for advancing IVF technology and making it even more accessible and efficient. After great discoveries and inventions in the field of sciences our understanding of human body has increased every day.
Few decades ago, things like IVF could have been considered an act of God something that could never be done by a mortal human. But look at the society today. More and more couples are using this technology to bring their dream to reality.
From the seeds of curiosity planted centuries ago to the birth of Louis Brown and beyond this remarkable journey has transformed the lives of millions. IVF has given hope to couples who once believed their dreams of parenthood were unattainable. As we look towards the future, we anticipate even greater discoveries and a continued legacy of compassion, hope and new beginnings.
Let us now look into the steps involved:
1. Preparation
2. Ovarian Stimulation
3. Egg Retrieval
4. Fertilization
5. Embryo Development
6. Embryo Transfer
7. Pregnancy
· The IVF treatment process begins long before any egg removal and fertilization takes place. You'll need a thorough medical history before treatment begins, plus fertility tests and analysis for you and your partner. As the procedure gets closer, you may be prescribed birth control pills or estrogen to control the timing of your menstrual cycle and maximize the number of mature eggs available for retrieval.
· During a typical ovarian cycle, only one egg becomes mature enough to ovulate. IVF treatment uses injectable hormone medication to bring a group of eggs to maturity to increase the odds of a successful pregnancy. The type, dosage, and frequency of the medication will be tailored specifically to you for optimal results. Monitoring of the eggs may occur daily or every few days during this time to determine when they mature. A final trigger shot is given exactly 36 hours before the scheduled egg retrieval to finalize the maturation process.
· Once the eggs are mature, it's time for egg retrieval. During this step, a suction device connected to a long thin needle is inserted through your vagina. This will puncture ovarian follicles and pull the mature eggs out. Removed eggs are placed in a Petri dish containing a special solution and then placed in an incubator for a short period of time. Since this procedure is mildly invasive, medication and sedation are used.
· Fertilization of the eggs takes place within a day during a procedure known as an intracytoplasmic sperm injection. A single sperm is introduced into each mature egg. On average, about 70% of mature eggs will successfully fertilize.
· Now comes the growing and waiting. Fertilized eggs are monitored and left to develop over the next several days with cells actively divided. About half of fertilized embryos will progress to the blastocyst stage when they are suitable for transfer into a uterus. Embryos that are suitable for transfer can either be used right away or frozen for future transfer.
· Within a week after fertilization, it's time to transfer the embryos. This is a short procedure that only takes about 10 minutes and feels very similar to a pelvic exam or a pap smear. A speculum is placed within the vagina and a thin catheter is inserted through the cervix into the uterus. An embryo or embryos are then injected through the catheter into the uterus. After an embryo transfer, you may experience symptoms such as mild bloating and cramping, breast tenderness from high oestrogen levels, spotting, and constipation.
· Within 14 days after the embryo transfer, a blood test will be done to determine if you're pregnant. If the pregnancy test is positive, you begin the journey of prenatal care.
Pregnancy success rates per embryo transfer vary depending on the age of the woman at the time of egg retrieval. If the pregnancy test is negative, you can try another embryo transfer if you have additional embryos frozen from the first IVF cycle. If you do not have remaining embryos, you can try IVF again. IVF has been used successfully for more than four decades. Talk openly with your health care provider about your options.
Embryology course Eligibility – What you need to know?
Founded by pioneer in the field of Infertility, Medline Academics is one of the best training institutes for formal education in embryology. With their fellowship program, you have access to Basic Andrology, Clinical Embryology course in Bangalore, Advanced Embryology, Genetics, Research Methodology and Quality Assurance in Embryology Laboratory. With the practical training, you will learn about semen analysis, semen sample preparation, ovum pick up, denudation, dish preparation, immobilization, alignment of micromanipulator, ICSI, IMSI, Embryo culturing, Assisted Hatching, Vitrification of embryos and oocytes, thawing of embryos and oocytes and Embryo transfer. Formal training in embryology is a rigorous and intellectually challenging process that prepares students for careers in a wide range of fields, including academia, medicine, biotechnology, and government research. By studying the complex and dynamic process of embryonic development, embryologists can contribute to our understanding of human health and disease, as well as the evolution of life on Earth.
Along with the embryology course eligibility, you should also know the embryology course fees in India to know and apply to the best institution and pursue your career in this evolving field.
That was about the learning, now let’s come to the earnings! Wondering where you can work as a qualified embryologist after completing the course. Dr. Kamini Rao Hospitals located in the heart of South Bangalore, is a premium destination for practicing IVF. Being one of the best IVF Centre in Bangalore, it allows you to practice in their hospital based on your merit. To learn more about this, visit our official website.
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